IRDye® 700DX NHS Ester

Basic Information

structure
IRDye® 700DX NHS Ester
Also called "IR700" when attached to primary antibodies for in vivo imaging
Silicate(4-), [2,5-dioxo-1-pyrrolidinyl 6-[[[3-[(29H,31H-phthalocyanin-1-yl-kapp...
916821-46-0
C74 H96 N12 O27 S6 Si3 • 4Na
1954.22g / Mol
Phthalocyanine
• Polyprotic molecular weight = 1866.30 for mass spectrometry analysis • Near-infrared (NIR) fluorescent dye • Solubility: Water or DMSO • NHS ester for conjugation to amino and hydroxyl groups • Supplied as polysodium salt • Used for making optical probes for NIR fluorescence imaging • Siloxy sidechains (MW = 499.69) acid-labile • Implications for photoimmunotherapy (see references)

References

1
Dynamic fluorescent imaging with indocyanine green for monitoring the therapeutic effects of photoimmunotherapy., DOI: 10.1002/cmmi.1570
2
Potent and specific antitumor effect of CEA-targeted photoimmunotherapy., DOI: 10.1002/ijc.28907
3
Cannabinoid CB2 Receptor as a New Phototherapy Target for the Inhibition of Tumor Growth, DOI: 10.1021/mp5001923
4
Target-selective phototherapy using a ligand-based photosensitizer for type 2 cannabinoid receptor., DOI: 10.1016/j.chembiol.2014.01.009.

Overview

689 nm
699 nm
PBS PH 7.40
165000 M-1cm-1

Absorption

689 nm
165000 M-1cm-1
-

Emission

699 nm
no
-
-

More parameters

PBS PH 7.40
-

spectra uploaded by Lael Cheung

Provide more Spectra

Quantum Yields


Lifetimes


Availabilities

Commercial
LI-COR Biosciences (USA & Worldwide Distributor Information)
http://www.licor.com/bio/products/reagents/irdye/700dx/nhs_ester.html
biosales@licor.com
Commercial
LI-COR Biosciences GmBH (Germany, Austria, & Switzerland)
http://www.licor.com/bio/products/reagents/irdye/700dx/nhs_ester.html
bio-eu@licor.com
Commercial
LI-COR Biosciences Ltd (UK, Ireland, & Scandinavia)
http://www.licor.com/bio/products/reagents/irdye/700dx/nhs_ester.html
bio-eu@licor.com
Commercial
Japan: M&S TechnoSystems, Inc.
http://www.mstechno.co.jp/
technosales@technosaurus.co.jp
Commercial
China: Gene Company Ltd.
http://www.genecompany.com/
sales@genehk.com
Commercial
South Korea: Dong Young Instruments Co., Ltd.
http://www.dongyoung.co.kr/sub/index.php
product@dongyoung.co.kr
Commercial
Australia: Millennium Science Pty. Ltd.
http://www.mscience.com.au/
sales@mscience.com.au
Commercial
India: Inkarp Instruments Pvt. Ltd.
http://inkarp.co.in/
info@inkarp.co.in

Applications

Photoimmunotherapy
Photoimmunotherapy: Comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor.
10.1016/j.molonc.2014.01.006.
fluorescent labeling
GPCR Ligand Dendrimer (GLiDe) Conjugates: Adenosine Receptor Interactions of a Series of Multivalent Xanthine Antagonists
10.1021/bc1005812
fluorescent labeling
Ginger-derived nanoparticles protect against alcohol-induced liver damage
10.3402/jev.v4.28713
Photoimmunotherapy
Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model
10.18632/oncotarget.3850
Photoimmunotherapy
Near Infrared Photoimmunotherapy Targeting EGFR Positive Triple Negative Breast Cancer: Optimizing the Conjugate-Light Regimen
10.1371/journal.pone.0136829
Photoimmunotherapy
Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700-antibody conjugates.
10.1016/j.freeradbiomed.2015.03.038
Photoimmunotherapy
Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models
10.1016/j.jss.2015.02.037
Photoimmunotherapy
Near Infra-Red Photoimmunotherapy with Anti-CEA-IR700 Results in Extensive Tumor Lysis and a Significant Decrease in Tumor Burden in Orthotopic Mouse Models of Pancreatic Cancer
10.1371/journal.pone.0121989
Photoimmunotherapy
Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies?
10.2967/jnumed.114.149526
Photoimmunotherapy
A standardized light-emitting diode device for photoimmunotherapy
10.2967/jnumed.114.142299
Immunofluorescence
Click-EM for imaging metabolically tagged nonprotein biomolecules
10.1038/nchembio.2076