IRDye® QC-1 NHS Ester

Basic Information

structure
IRDye® QC-1 NHS Ester
QC-1 Quencher Dye NHS Ester
1H-Benz[e]indolium, 2-[2-[3-[2-[5-[bis(3-sulfopropyl)amino]-1,3-dihydro-3,3-dime...
918324-42-2
C53 H62 Cl N4 O16 S4 • 3Na
1243.76g / Mol
Cyanine
• Polyprotic molecular weight = 1177.81 for mass spectrometry analysis. • Broad-spectrum FRET quencher (effective over 500 to 800 nm emission range) • Solubility: Water or DMSO • NHS ester for conjugation to amino and hydroxyl groups • Supplied as polysodium salt • Used for making activatable probes for NIR fluorescence imaging

References

1
A nonfluorescent, broad-range quencher dye for Förster resonance energy transfer assays., DOI: 10.1016/j.ab.2009.02.024
2
Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate, DOI: 10.1371/journal.pone.0079065
3
Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring., DOI: 10.1038/cdd.2009.120
4
Near-Infrared Fluorescence Imaging of Mammalian Cells and Xenograft Tumors with SNAP-Tag, DOI: 10.1371/journal.pone.0034003
5
An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura, DOI: 10.1111/jth.12319

Overview

738 nm
PBS PH 7.40
96000 M-1cm-1

Absorption

738 nm
96000 M-1cm-1
-

Emission

no
-
-

More parameters

PBS PH 7.40
-

spectra uploaded by Lael Cheung

Provide more Spectra

Quantum Yields


Lifetimes


Availabilities

Commercial
LI-COR Biosciences (USA & Worldwide Distributor Information)
http://www.licor.com/bio/products/reagents/irdye/QC1/products.html
biosales@licor.com
Commercial
LI-COR Biosciences GmBH (Germany, Austria, Switzerland, & France)
http://www.licor.com/bio/products/reagents/irdye/QC1/products.html
bio-eu@licor.com
Commercial
LI-COR Biosciences Ltd (UK, Ireland, Scandinavia, & Iceland)
http://www.licor.com/bio/products/reagents/irdye/QC1/products.html
bio-eu@licor.com
Commercial
Japan: M&S TechnoSystems, Inc.
http://www.mstechno.co.jp/
technosales@technosaurus.co.jp
Commercial
China: Gene Company Ltd.
http://www.genecompany.com/
sales@genehk.com
Commercial
South Korea: Dong Young Instruments Co., Ltd.
http://www.dongyoung.co.kr/sub/index.php
product@dongyoung.co.kr
Commercial
Australia: Millennium Science Pty. Ltd.
http://www.mscience.com.au/
sales@mscience.com.au
Commercial
India: Inkarp Instruments Pvt. Ltd.
http://inkarp.co.in/
info@inkarp.co.in

Applications

FRET Quenching
Optimal dye-quencher pairs for the design of an "activatable" nanoprobe for optical imaging.
10.1039/c3pp50118c
FRET Quenching
Photodynamic Quenched Cathepsin Activity Based Probes for Cancer Detection and Macrophage Targeted Therapy
10.7150/thno.10854
FRET Quenching
A homogeneous fluorescence-based method to measure antibody internalization in tumor cells
10.1016/j.ab.2014.09.008
FRET Quenching
A Cell-Based Internalization and Degradation Assay with an Activatable Fluorescence–Quencher Probe as a Tool for Functional Antibody Screening
10.1177/1087057115588511