IRDye® 700DX Carboxylate

Basic Information

structure
IRDye® 700DX Carboxylate
Also called "IR700" when attached to primary antibodies for in vivo imaging
C70H92 N11 O25 S6 Si3 • 5Na
1877.34g / Mol
Phthalocyanine
Polyprotic molecular weight = 1769.22 for mass spectrometry analysis • Near-infrared (NIR) fluorescent dye • Solubility: Water or DMSO • NHS ester for conjugation to amino and hydroxyl groups • Supplied as polysodium salt • Used for making optical probes for NIR fluorescence imaging • Siloxy sidechains (MW = 499.69) acid-labile • Reportedly capable of photoimmunotherapy (see references)

References

1
Improving the Efficacy of Photoimmunotherapy (PIT) using a Cocktail of Antibody Conjugates in a Multiple Antigen Tumor Model. , DOI: 10.7150/thno.5908
2
Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors., DOI: 10.1021/nn305011p
3
Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging., DOI: 10.1158/0008-5472.CAN-12-1298
4
Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy., DOI: 10.1186/1471-2407-12-345
5
Direct Characterization of Arterial Input Functions by Fluorescence Imaging of Exposed Carotid Artery to Facilitate Kinetic Analysis., DOI: 10.1007/s11307-013-0715-y

Overview

680 nm
687 nm
Methanol
210000 M-1cm-1

Absorption

680 nm
210000 M-1cm-1
-

Emission

687 nm
no
-
-

More parameters

Methanol
-

spectra uploaded by Lael Cheung

Provide more Spectra

Quantum Yields

44%
Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation
10.1088/0031-9155/61/10/3955

Lifetimes


Availabilities

Commercial
LI-COR Biosciences (USA & Worldwide Distributor Partners)
http://www.licor.com/bio/services/custom_labeling/
biosales@licor.com
Commercial
LI-COR Biosciences GmBH (Germany, Austria, & Switzerland)
http://www.licor.com/bio/services/custom_labeling/
bio-eu@licor.com
Commercial
LI-COR Biosciences Ltd (UK, Ireland, and Scandinavia)
http://www.licor.com/bio/services/custom_labeling/
bio-eu@licor.com
Commercial
Japan: M&S TechnoSystems, Inc.
http://www.mstechno.co.jp/
technosales@technosaurus.co.jp
Commercial
China: Gene Company Ltd.
http://www.genecompany.com/
sales@genehk.com
Commercial
South Korea: Dong Young Instruments Co., Ltd.
http://www.dongyoung.co.kr/sub/index.php
product@dongyoung.co.kr
Commercial
Australia: Millennium Science Pty. Ltd.
http://www.mscience.com.au/
sales@mscience.com.au
Commercial
India: Inkarp Instruments Pvt. Ltd.
http://inkarp.co.in/
info@inkarp.co.in

Applications

Photoimmunotherapy
Reference:Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.
10.1038/nm.2554
Cherenkov luminescence
Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation
10.1088/0031-9155/61/10/3955